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Example Input Mode:
Partner Data
CBIS
Matrix
Example Data Type:
Secondary Screen (Kd)
Primary Screen(% control or competition)
If the input file contains Primary and Secondary Data, use:
Primary
Secondary
Assay Data File:
.txt or .csv format - download examples:
Bromodomain
Kd
Primary
To highlight spots, select a compound(s), click 'fill' and select entries.
Create Images for:
AMG-706
Highlight These Spots (
fill
):
AMG-706|ABL1-nonphosphorylated|680
AMG-706|ABL2|4500
AMG-706|AURKC|1900
AMG-706|BLK|2200
AMG-706|BRAF|630
AMG-706|BRK|1000
AMG-706|CIT|300
AMG-706|CSF1R|5.6
AMG-706|DDR1|260
AMG-706|EGFR|1300
AMG-706|EPHA6|490
AMG-706|FGFR1|6200
AMG-706|FGFR4|6800
AMG-706|FGR|6900
AMG-706|FLT1|12
AMG-706|FLT3|71
AMG-706|FLT4|9.7
AMG-706|FRK|99
AMG-706|FYN|2800
AMG-706|GCN2(Kin.Dom.2,S808G)|4400
AMG-706|HCK|8600
AMG-706|JAK1(JH1domain-catalytic)|5200
AMG-706|KIT|3.7
AMG-706|LCK|360
AMG-706|LOK|1100
AMG-706|LYN|160
AMG-706|MAP3K2|6900
AMG-706|MAP3K3|2100
AMG-706|MAP4K4|5800
AMG-706|PDGFRA|10
AMG-706|PDGFRB|9.1
AMG-706|RAF1|880
AMG-706|RET|14
AMG-706|RIPK2|9300
AMG-706|SLK|1300
AMG-706|STK35|5400
AMG-706|TAK1|1300
AMG-706|TNNI3K|220
AMG-706|VEGFR2|26
AMG-706|YES|5000
AMG-706|YSK4|200
AMG-706|ZAK|8
AMG-706|ABL1-nonphosphorylated
AMG-706|ABL2
AMG-706|AURKC
AMG-706|BLK
AMG-706|BRAF
AMG-706|BRK
AMG-706|CIT
AMG-706|CSF1R
AMG-706|DDR1
AMG-706|EGFR
AMG-706|EPHA6
AMG-706|FGFR1
AMG-706|FGFR4
AMG-706|FGR
AMG-706|FLT1
AMG-706|FLT3
AMG-706|FLT4
AMG-706|FRK
AMG-706|FYN
AMG-706|GCN2(Kin.Dom.2,S808G)
AMG-706|HCK
AMG-706|JAK1(JH1domain-catalytic)
AMG-706|KIT
AMG-706|LCK
AMG-706|LOK
AMG-706|LYN
AMG-706|MAP3K2
AMG-706|MAP3K3
AMG-706|MAP4K4
AMG-706|PDGFRA
AMG-706|PDGFRB
AMG-706|RAF1
AMG-706|RET
AMG-706|RIPK2
AMG-706|SLK
AMG-706|STK35
AMG-706|TAK1
AMG-706|TNNI3K
AMG-706|VEGFR2
AMG-706|YES
AMG-706|YSK4
AMG-706|ZAK
AMG-706|ABL1-nonphosphorylated|680
AMG-706|ABL2|4500
AMG-706|AURKC|1900
AMG-706|BLK|2200
AMG-706|BRAF|630
AMG-706|BRK|1000
AMG-706|CIT|300
AMG-706|CSF1R|5.6
AMG-706|DDR1|260
AMG-706|EGFR|1300
AMG-706|EPHA6|490
AMG-706|FGFR1|6200
AMG-706|FGFR4|6800
AMG-706|FGR|6900
AMG-706|FLT1|12
AMG-706|FLT3|71
AMG-706|FLT4|9.7
AMG-706|FRK|99
AMG-706|FYN|2800
AMG-706|GCN2(Kin.Dom.2,S808G)|4400
AMG-706|HCK|8600
AMG-706|JAK1(JH1domain-catalytic)|5200
AMG-706|KIT|3.7
AMG-706|LCK|360
AMG-706|LOK|1100
AMG-706|LYN|160
AMG-706|MAP3K2|6900
AMG-706|MAP3K3|2100
AMG-706|MAP4K4|5800
AMG-706|PDGFRA|10
AMG-706|PDGFRB|9.1
AMG-706|RAF1|880
AMG-706|RET|14
AMG-706|RIPK2|9300
AMG-706|SLK|1300
AMG-706|STK35|5400
AMG-706|TAK1|1300
AMG-706|TNNI3K|220
AMG-706|VEGFR2|26
AMG-706|YES|5000
AMG-706|YSK4|200
AMG-706|ZAK|8
clear
Select Highlight spots color from Pallette:
(also used in table view)
Tree Image Options
Restore default options
Spot options:
IndianRed
PaleGreen
Gold
PowderBlue
Fill?
Outline?
Outline thickness:
1
2
3
4
5
Select Spots Color from Pallette:
(spot highlight color below)
micro
nano
Spot Size:
Scaling Factor:
.1
.2
.3
.4
.5
.6
.7
.8
.9
1
1.1
1.2
1.3
Area increase factor:
100%
90%
80%
70%
60%
50%
(per change of 10x Kd or 10% Competition)
Legend options:
Left align Text
Right align Text
Label options:
Compound Name?
Compound Name Font:
.5
1
1.5
2
Show Assay Panel information?
Show Panel Spots?
Append Concentration? (i.e., 'AB500@1000nm'; check before loading.)
Background Image:
Target labels?
Dark Tree Branch image?
Hide Lipid, Mutant, ATypical and Pathogen?
Spot options:
Spot Color transparency level:
none
low
medium-low
medium
high
no color
Spot Cutoff Value:
Kd (nM) (Blank for no cutoff)
Spot outline only?
Format:
JPEG(200KB per image)
Publication Quality(5MB image)
Create Publication Quality (5MB bitmap) Image for:
Select Compound
AMG-706
size/quality
100
90
80
70
60
50
40
30
% of original
White Space Border:
Yes
No
Preview and Highlighting
Highlight an assay by clicking on the spot or checking the box next to the Gene Symbol Name.
Click 'Update' to create the new images.
Compound To Highlight:
None
AMG-706
Highlight Panel?
* WildType kinase assays appear in both the main TREEspot and Mutant kinase dendrogams.
Human Kinome image created by KINOMEscan.
2 images created. To download (copy and paste) all images to your local machine click Open/Browse Image Folder.
Images Saved To:
D:\Eurofins\PROD\Applications\FrontOffice_Discovery\StudyManagement\TreeSpot\HTSTools\TreeImages\17_woo2ospa4uu5kxwfxlyojwhm\
Open/Browse Image Folder
View Options:
(These options do not modify the images that have been created, only the view on this page)
AMG-706
Legend
Show Selected
Size:
Select Size
small
medium
full size
Images per Row:
1
Legend Resize?
Hover the cursor to identify spots and click to highlighted it. To save an image click the Zoom/Download link.
Zoom/Download
Highlight
Locate an Assay
ABL1-nonphosphorylated
ABL1-nonphosphorylated
AURKC
BLK
BRAF
BRAF
BRK
CIT
CSF1R
DDR1
EGFR
EGFR
EPHA6
FLT1
FLT3
FLT3
FLT4
FRK
FYN
KIT
KIT
LCK
LOK
LYN
MAP3K3
PDGFRA
PDGFRB
RAF1
RET
RET
SLK
TAK1
TNNI3K
VEGFR2
YSK4
ZAK
Legend
Data Table View:
Show All Data
Only Selected Compounds/Trees
TREE
spot
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